2-amino-6-fluoro-N-methylbenzamide → Diethyl (4-{[4-{[3-fluoro-2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

HRID 511375Notes

Reaction equation

HRID 511375 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[CH:13][N:12]=[C:11]([NH:19][C:20]3[CH:34]=[CH:33][C:23]([CH2:24][P:25](=[O:32])([O:29][CH2:30][CH3:31])[O:26][CH2:27][CH3:28])=[CH:22][C:21]=3[O:35][CH3:36])[N:10]=2)=[C:4]([C:37](=[O:40])[NH:38][CH3:39])[CH:3]=1.ClC1C(C(F)(F)[F:49])=CN=C(NC2C=CC(CP(=O)(OCC)OCC)=CC=2OC)N=1.NC1C=CC=C(F)C=1C(NC)=O>>[F:49][C:3]1[C:4]([C:37](=[O:40])[NH:38][CH3:39])=[C:5]([NH:8][C:9]2[C:14]([C:15]([F:16])([F:18])[F:17])=[CH:13][N:12]=[C:11]([NH:19][C:20]3[CH:34]=[CH:33][C:23]([CH2:24][P:25](=[O:32])([O:26][CH2:27][CH3:28])[O:29][CH2:30][CH3:31])=[CH:22][C:21]=3[O:35][CH3:36])[N:10]=2)[CH:6]=[CH:7][CH:2]=1

Participants

4

Reactant 3

HCID 208067942-amino-6-fluoro-N-methylbenzamide2×HCID 49822431Diethyl (4-{[4-{[4-fluoro-2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonateHCID 86654002Diethyl (4-{[4-chloro-5-(trifluoromethyl) pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

Product 1

HCID 58292932Diethyl (4-{[4-{[3-fluoro-2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

Procedure

The title compound was prepared according to the procedure from Example 102 (Diethyl (4-{[4-{[4-fluoro-2-(methylcarbamoyl)-phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate) using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 2-amino-6-fluoro-N-methylbenzamide (Compound 155A). 1H NMR (DMSO-d6, 400 MHz): δ=1.19 (t, J=7.07 Hz, 6 H), 2.76 (d, J=4.80 Hz, 3 H), 3.19-3.27 (m, 2 H), 3.76 (s, 3 H), 3.93-4.02 (m, 4 H), 6.78-6.83 (m, 1 H), 6.97-7.03 (m, 2 H), 7.38 (d, J=7.07 Hz, 1 H), 7.49 (d, J=6.82 Hz, 1 H), 8.00 (br. s., 1 H), 8.38 (s, 1 H), 8.62 (d, J=3.79 Hz, 1 H), 8.80 (br. s., 1 H), 9.78 (s, 1 H). MS (ES+): m/z 586.14 [MH+] (TOF, polar).

Sources & evidence

ORD record
ord-e5274300186e4f558b6b3bebb3f19691
Source dataset
uspto-grants-2015_08
Patent number
US09096624B2

Reaction notes

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