反应详情

A solution of 2-(2-methylpyrimidin-5-yl)acetonitrile (4 g, 0.03 amol) and methyl acrylate (5.69 g, 0.066 mol) in THF (60 mL) was added t-BuOK (93 mL, 0.093 mol, 1M in THF) and stirred at room temperature for 4 h. The reaction mixture was quenched by sat. NH4Cl and extracted with EtOAc (3×150 mL). The organic layer was dried over Na2SO4 and concentracted to give methyl 5-cyano-2-hydroxy-5-(2-methylpyrimidin-5-yl)cyclohex-1-enecarboxylate (5.5 g), which was used for the next step directly.

1. customThe reaction mixture was quenched by sat. NH4Cl
2. extractionextracted with EtOAc (3×150 mL)
3. dry with materialThe organic layer was dried over Na2SO4