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HRID512621

反应详情

EQUATION

反应方程式

HRID 512621 的结构方程式

REACTANTS

反应物

2
结构：COc1cc(-c2ccco2)cc(OC)c1Br
HCID58431988

未命名化合物

结构：CCc1nnc(-c2ccc(C(OC)C(=O)N(C)OC)cc2)o1
HCID58432135

2-(4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenyl)-N,2-dimethoxy-N-methylacetamide

C15H19N3O4

PRODUCTS

生成物

1
结构：CCc1nnc(-c2ccc(C(OC)C(=O)c3ccc(-c4cc(OC)c(Br)c(OC)c4)o3)cc2)o1
HCID58432026

未命名化合物

收率 12%

PROCEDURE

实验过程

The method used for the final coupling step of Example 12 was followed for the reaction of 2-(4-bromo-3,5-dimethoxyphenyl)furan with 2-(4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenyl)-N,2-dimethoxy-N-methylacetamide. Purification by chromatography (20-100% EtOAc-hexanes) gave 1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-(4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenyl)-2-methoxyethanone as a yellow foam (0.037 g, 12% yield). MS: m/z 527.1 [M+H]+.

WORKUP

后处理

  1. customPurification by chromatography (20-100% EtOAc-hexanes)