反应详情

N,2-Dimethoxy-N-methyl-2-(4-(morpholinomethyl)phenyl)acetamide was coupled with 2-(4-bromo-3,5-dimethoxyphenyl)furan following the procedure of Example 12. Purification by chromatography (0-9% NH3-MeOH in CH2Cl2; 0.7 M NH3-MeOH used) gave a mixture which was digested with EtOAc at 30-40° C. After cooling to room temperature, the crystals were collected on a Büchner, rinsed with EtOAc and dried in vacuo to give 1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-(morpholinomethyl)phenyl)ethanone as a white solid. A second batch was also isolated (0.125 g for two batches, 13% yield). MS: m/z 530.1 [M+H]+.

1. customPurification by chromatography (0-9% NH3-MeOH in CH2Cl2; 0.7 M NH3-MeOH used)
2. customgave a mixture which
3. customthe crystals were collected on a Büchner
4. washrinsed with EtOAc
5. customdried in vacuo