Phosphoryloxychloride → HCID 86704353, compound

HRID 515134Notes

Reaction equation

[CH:1]1([NH:4][C:5](=O)[CH2:6][NH:7][C:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[S:9])[CH2:3][CH2:2]1.P(Cl)(Cl)(O[Cl:20])=O>C(#N)C>[ClH:20].[CH:1]1([NH:4][C:5]2[S:9][C:8]([C:10]3[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=3)=[N:7][CH:6]=2)[CH2:3][CH2:2]1

Participants

Conditions

Temperature: 100 °C

Procedure

N-Cyclopropyl-2-(pyridine-3-carbothioamido)acetamide (1.00 g, 4.25 mmol) was dissolved in acetonitrile (5 mL) in a dry flask and phosphoryloxy trichloride (3.26 g, 21.25 mmol) was added, dropwise. The mixture was warmed to 100° C. and stirred for 1 hour. The mixture was cooled to room temperature and the yellow solid filtered under vacuum. This solid was washed with acetonitrile and dried under vacuum to give 0.36 g of N-cyclopropyl-2-(pyridin-3-yl)thiazol-5-amine HCl salt (LCMS and 1H-NMR indicated 100% purity). The filtrate was diluted with ethyl acetate and carefully basified with saturated aqueous NaHCO3. The organic phase was separated and washed with brine, dried over MgSO4, and concentrated in vacuo to give N-cyclopropyl-2-(pyridin-3-yl)thiazol-5-amine as a brown oil (0.45 g, 3.47 mmol, 82%): 1H NMR (400 MHz, CDCl3) δ 9.10 (d, J=2.1 Hz, 1H), 8.68 (dd, J=5.5, 1.2 Hz, 1H), 8.63-8.58 (m, 1H), 7.89 (dd, J=8.1, 5.4 Hz, 1H), 7.07 (d, J=7.8, 1H), 2.57 (dt, J=10.0, 3.3 Hz, 1H), 0.85-0.68 (m, 2H), 0.57-0.45 (m, 2H); ESIMS (m/z) 216 ([M−H]−).

Workup

temperatureThe mixture was cooled to room temperature
filtrationthe yellow solid filtered under vacuum
washThis solid was washed with acetonitrile
customdried under vacuum

Sources & evidence

ORD record: ord-4826f93d59294afd804a475dc2370ed8
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09108952B2

Reaction notes

Loading…