反应详情

2-(4-(Bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (9.61 mmol, 4.63 mL, 3.24 g), 3-(4-nitrophenoxy)pyrrolidine (9.61 mmol, 2 g) and potassium carbonate (19.21 mmol, 2.65 g) were combined and stirred at room temperature in acetonitrile (50 mL) for 1 hour. The reaction mixture was filtered and concentrated under vacuum. The residue was purified by silica column chromatography (eluent: dichloromethane to 15% methanol in dichloromethane) and SCX chromatography to afford the intermediate 1,1,1,3,3,3-hexafluoro-2-(4-((3-(4-nitrophenoxy)pyrrolidin-1-yl)methyl)phenyl)propan-2-ol (750 mg).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated under vacuum
3. customThe residue was purified by silica column chromatography (eluent: dichloromethane to 15% methanol in dichloromethane) and SCX chromatography