反应详情

温度

100 °C

Phenyl N-[4-(4-amino-7-tetrahydro-2H-4-pyranyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]carbamate (30 mg, 0.065 mmol) was mixed with (5-methyl-3-isoxazolyl)methanol (0.05 mL) in pyridine (0.5 mL). The reaction mixture was heated at 100° C. overnight. The solvent was removed and the residue was purified by preparative reverse phase LC/MS to give (5-methyl-3-isoxazolyl)methyl N-[4-(4-amino-7-tetrahydro-2H-4-pyranyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]carbamate (18 mg, 0.038 mmol). 1H NMR (CDCl-d) δ 2.06(m, 4H), 2.44(s, 3H), 3.64(m, 2H), 3.91(s, 3H), 4.13(m, 2H), 4.96(m, 1H), 5.26 (s, 2H), 6.12(s, 1H), 6.95(s, 1H), 7.06(m, 2H), 7.39(s, 1H), 8.17(bs, 1H), 8.21(s, 1H). LC/MS: MH+479.

1. customThe solvent was removed
2. customthe residue was purified by preparative reverse phase LC/MS