反应详情

The mixture of 13.0 g (82.5 mmol) of 6-chloro-4,5-dimethylpyridazin-3-ylamine and 23.2 g (107 mmol) of 2-bromo-1-(4-fluorophenyl)ethanone in 130 ml of ethanol is refluxed for 16 hours. The solvent is evaporated off under reduced pressure, and the residue is taken up with chloroform and washed with a dilute solution of aqueous ammonia. The organic phase is dried over sodium sulfate and then concentrated under reduced pressure. The brown solid obtained is triturated in acetone, to give 19.2 g of a beige powder after filtration and drying.

1. temperatureis refluxed for 16 hours
2. customThe solvent is evaporated off under reduced pressure
3. washwashed with a dilute solution of aqueous ammonia
4. dry with materialThe organic phase is dried over sodium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe brown solid obtained
7. customis triturated in acetone