反应详情

Subsequently, 2.0 g (13.9 mmol) of the 4-bromobenzohydrazide obtained in (i) above was put in a 300-mL three-neck flask, 7 ml of N-methyl-2-pyrrolidone (abbreviation: NMP) was added thereto, and the mixture was stirred. Thereafter, a mixture of 2.5 mL of N-methyl-2-pyrrolidone and 2.5 mL (21.5 mmol) of benzoyl chloride was dripped through a 50-mL dropping funnel, and the mixture was stirred at 80° C. for 3 hours. The obtained solid was washed with water and a sodium carbonate aqueous solution in this order and collected by suction filtration. Then, the solid was recrystallized with acetone; thus, 3.6 g of a white solid of 1-benzoyl-2-(4-bromobenzoyl)hydrazine that was an object was obtained in the yield of 80%.

1. customabove was put in a 300-mL three-neck flask
2. stirringthe mixture was stirred at 80° C. for 3 hours
3. washThe obtained solid was washed with water
4. filtrationa sodium carbonate aqueous solution in this order and collected by suction filtration
5. customThen, the solid was recrystallized with acetone
6. customwas obtained in the yield of 80%