HRID517513

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13403316

未命名化合物

结构：COC(=O)[C@H](CNC(=O)c1ccc(O)cc1)N1CCN(S(C)(=O)=O)CC1

HCID67056914

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CNC(=O)c1ccc(OCC#CCO[Si](C)(C)C(C)(C)C)cc1)N1CCN(S(C)(=O)=O)CC1

HCID86667910

未命名化合物

收率 89.8%

PROCEDURE

实验过程

In a manner similar to example 4-5, starting from 400 mg (1 mmol) of methyl (S)-3-(4-hydroxybenzoylamino)-2-(4-methanesulphonylpiperazin-1-yl)propanoate (prepared as described in example 4-4) and from 270 mg (1.2 mmol) of tert-butyl(4-chloro-but-2-ynyloxy)-dimethylsilane; 510 mg (88%) of methyl (S)-3-{4-[4-(tert-butyldimethylsilanyloxy)but-2-ynyloxy]benzoyl-amino}-2-(4-methanesulphonylpiperazin-1-yl)propanoate are obtained in the form of a colourless oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d30af802f3ff49ddb1798a0ed7bd41f8
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09115102B2
来源说明: uspto-grants-2015_08

反应 SMILES

[OH:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([NH:8][CH2:9][C@H:10]([N:15]2[CH2:20][CH2:19][N:18]([S:21]([CH3:24])(=[O:23])=[O:22])[CH2:17][CH2:16]2)[C:11]([O:13][CH3:14])=[O:12])=[O:7])=[CH:4][CH:3]=1.[C:27]([Si:31]([O:34][CH2:35][C:36]#[C:37][CH2:38]Cl)([CH3:33])[CH3:32])([CH3:30])([CH3:29])[CH3:28]>>[Si:31]([O:34][CH2:35][C:36]#[C:37][CH2:38][O:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([NH:8][CH2:9][C@H:10]([N:15]2[CH2:16][CH2:17][N:18]([S:21]([CH3:24])(=[O:23])=[O:22])[CH2:19][CH2:20]2)[C:11]([O:13][CH3:14])=[O:12])=[O:7])=[CH:4][CH:3]=1)([C:27]([CH3:28])([CH3:29])[CH3:30])([CH3:32])[CH3:33]