4-Cyanobenzoic acid → HCID 178457787, compound

HRID 518649Notes

Reaction equation

HRID 518649 reaction equation
[CH:1]([NH:4][C:5]([C@@H:7]1[CH2:12][CH2:11][C@H:10]([N:13]2[C:21]3[CH:20]=[C:19]([O:22][CH2:23][CH2:24][N:25]4[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]4)[N:18]=[CH:17][C:16]=3[NH:15]/[C:14]/2=[N:31]\[C:32]([C:34]2[CH:35]=[CH:36][C:37]3[CH:41]=CS[C:38]=3[CH:42]=2)=[O:33])[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].C(C1C=CC(C(O)=O)=CC=1)#[N:44]>>[C:41]([C:37]1[CH:38]=[CH:42][C:34]([C:32](/[N:31]=[C:14]2/[N:13]([C@H:10]3[CH2:9][CH2:8][C@@H:7]([C:5](=[O:6])[NH:4][CH:1]([CH3:2])[CH3:3])[CH2:12][CH2:11]3)[C:21]3[CH:20]=[C:19]([O:22][CH2:23][CH2:24][N:25]4[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]4)[N:18]=[CH:17][C:16]=3[NH:15]/2)=[O:33])=[CH:35][CH:36]=1)#[N:44]

Participants

3

Reactant 2

HCID 120874-Cyanobenzoic acidHCID 178457785HCID 178457785, compound

Product 1

HCID 178457787HCID 178457787, compoundYield 34.6%

Procedure

The title compound was prepared using a method analogous to the preparation of (E)-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzo[b]thiophene-6-carboxamide, using 4-cyanobenzoic acid. After preparative HPLC purification, the TFA salt was free-based using an SCX-ion exchange column to obtain (E)-4-cyano-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzamide as a light yellow solid (34.6% yield). MS m/z=558.2 [M+H], calc 557.69 for C31H39N7O3.

Workup

  1. customThe title compound was prepared
  2. customAfter preparative HPLC purification

Sources & evidence

ORD record
ord-a8c792c94c7b42b8b8cff01ef21e7e89
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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