3-Methoxybenzoic Acid → HCID 178490496, Verbindung

HRID 518654Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 518654
[CH:1]([NH:4][C:5]([C@@H:7]1[CH2:12][CH2:11][C@H:10]([N:13]2[C:21]3[CH:20]=[C:19]([O:22][CH2:23][CH2:24][N:25]4[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]4)[N:18]=[CH:17][C:16]=3[NH:15]/[C:14]/2=[N:31]\[C:32]([C:34]2[CH:35]=[CH:36][C:37]3C=CS[C:38]=3[CH:42]=2)=[O:33])[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].[CH3:43][O:44]C1C=C(C=CC=1)C(O)=O>>[CH:1]([NH:4][C:5]([C@@H:7]1[CH2:12][CH2:11][C@H:10]([N:13]2[C:21]3[CH:20]=[C:19]([O:22][CH2:23][CH2:24][N:25]4[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]4)[N:18]=[CH:17][C:16]=3[NH:15]/[C:14]/2=[N:31]\[C:32](=[O:33])[C:34]2[CH:35]=[CH:36][CH:37]=[C:38]([O:44][CH3:43])[CH:42]=2)[CH2:9][CH2:8]1)=[O:6])([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 114613-Methoxybenzoic AcidHCID 178457785HCID 178457785, Verbindung

Produkt 1

HCID 178490496HCID 178490496, VerbindungAusbeute 42,5 %

Versuchsvorschrift

The title compound was prepared using a method analogous to the preparation of (E)-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzo[b]thiophene-6-carboxamide, using 3-methoxybenzoic acid. The material was purified via preparative HPLC (0.1% NH4OH in ACN/H2O) to provide (E)-N(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)-3-methoxy-benzamide (42.5% yield). MS m/z=563.4 [M+H], calc 562.71 for C31H42N6O4.

Aufarbeitung

  1. customThe title compound was prepared
  2. customThe material was purified via preparative HPLC (0.1% NH4OH in ACN/H2O)

Quellen und Nachweise

ORD-Eintrag
ord-f36b1de044884cb8a8cfa7d773816a5f
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09115127B2

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