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HRID518698

反应详情

EQUATION

反应方程式

HRID 518698 的结构方程式

REACTANTS

反应物

2
结构：CC(C)NC(=O)[C@H]1CC[C@@H](Nc2cc(OCCn3cncn3)ncc2N)CC1
HCID178457862

未命名化合物

结构：COCCOc1cc2c(cn1)[nH]/c(=N\C(=O)c1ccc(F)cc1)n2[C@H]1CC[C@@H](C(=O)NC(C)C)CC1
HCID178496069

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3cnc(OCCn4cncn4)cc32)CC1
HCID178457813

未命名化合物

收率 43%

PROCEDURE

实验过程

The title compound was prepared from cis-4-(2-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-5-aminopyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide using a procedure analogous to that used to prepare (E)-4-fluoro-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-methoxyethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzamide. Isolated as an off-white solid (62 mg, 43% yield, last step). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=6.55 Hz, 6H) 1.57-1.62 (m, 2H) 1.69-1.73 (m, 2H) 2.02-2.16 (m, 2H) 2.50-2.51 (m, 1H) 2.57-2.79 (m, 2H) 3.92-4.02 (m, 1H) 4.60-4.65 (m, 4H) 4.70-4.80 (m, 1H) 6.99 (s, 1H) 7.25 (dd, J=8.85, 8.85 Hz, 2H) 7.65 (d, J=7.82 Hz, 1H) 7.98 (s, 1H) 8.22 (s, 1H) 8.28-8.36 (m, 2H) 8.53 (s, 1H) 12.70 (s, 1H). M/Z calc'd for C27H31FN8O3: 534.59. found 535 [M+H].

WORKUP

后处理

  1. customIsolated as an off-white solid (62 mg, 43% yield, last step)