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HRID518707

反应详情

EQUATION

反应方程式

HRID 518707 的结构方程式

REACTANTS

反应物

2
反应SMILES：CC(C)NC(=O)[C@H]1CC[C@@H](Nc2cc(OC3CCN(C)CC3)ncc2N)CC1
HCID178457850

未命名化合物

反应SMILES：COCCOc1cc2c(cn1)[nH]/c(=N\C(=O)c1ccc(F)cc1)n2[C@H]1CC[C@@H](C(=O)NC(C)C)CC1
HCID178496069

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3cnc(OC4CCN(C)CC4)cc32)CC1
HCID178457808

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from cis-4-(5-amino-2-(1-methylpiperidin-4-yloxy)pyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide using a procedure analogous to that used for (E)-4-fluoro-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-methoxyethoxy)-1H-imidazo[4,5-c]pyridin-2 (3H)-ylidene)benzamide. The product was isolated as an off-white solid (94 mg, 72% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.10 (d, J=8H, 6H) 1.48-1.78 (m, 7H) 1.84-2.03 (m, 2H) 2.04-2.10 (m, 2H) 2.13-2.34 (m, 5H) 2.65 (m, 4H) 3.95-4.05 (m, 1H) 4.65-4.80 (m, 1H) 4.89-5.03 (m, 1H) 6.96 (s, 1H) 7.26 (dd, J=8.75 Hz, 2H) 7.68 (d, J=7.63 Hz, 1H) 8.23 (s, 1H) 8.31 (dd, J=8.56, 5.82 Hz, 2H) 12.60 (br. s., 1H). M/Z calc'd for C29H37FN6O3: 536.64. found 537 [M+H].