反应详情

To a solution of tert-butyl 4-(1-methyl-2-oxo-8-(trifluoromethyl)-3-((2-(trimethylsilyl)ethoxy)methyl)-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)-5,6-dihydropyridine-1(2H)-carboxylate (0.07 g, 0.117 mmol) in MeOH (15 mL) was added Pd/C (10%, 0.010 g) and the reaction mixture was stirred under an atmosphere of H2 (1 atm) for 20 h. The reaction mixture was filtered, washing with methanol (3×5 mL). The filtrate was concentrated in vacuo to give tert-butyl 4-(1-methyl-2-oxo-8-(trifluoromethyl)-3-((2-(trimethylsilyl)ethoxy)methyl)-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)piperidine-1-carboxylate (0.07 g, 100%), which was used directly in the next step.

1. filtrationThe reaction mixture was filtered
2. washwashing with methanol (3×5 mL)
3. concentrationThe filtrate was concentrated in vacuo