反应详情

温度

120 °C

3-Fluoro-1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine (660 mg), Pd(PPh3)4 (168 mg) and 4-bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (613 mg) were weighed into a microwave vial and DMF (10 ml) was added. The mixture was heated to 120° C. overnight. The mixture was then cooled to RT and the solvent was removed in vacuo. The crude material was dried in a vacuum oven overnight. The resulting dark brown oil was purified by FlashMaster II. The crude material was dissolved in chloroform and added to the top of 2×100 g silica SPE cartridges that were subsequently eluted with 0-100% ethyl acetate:cyclohexane over 80 min. The product-containing fractions were combined and the solvent removed in vacuo to give the title compound, 357 mg as a cream solid.

1. additionwas added
2. temperatureThe mixture was then cooled to RT
3. customthe solvent was removed in vacuo
4. dry with materialThe crude material was dried in a vacuum oven overnight
5. customThe resulting dark brown oil was purified by FlashMaster II
6. dissolutionThe crude material was dissolved in chloroform
7. additionadded to the top of 2×100 g silica SPE cartridges that
8. washwere subsequently eluted with 0-100% ethyl acetate
9. customthe solvent removed in vacuo