反应详情

2-Bromo-5-fluoro-pyridine (2.46 g, 13.98 mmol) in tetrahydrofuran (20 mL) is added drop wise to isopropylmagnesium chloride (15 mL, 30.00 mmol of a 2M solution in tetrahydrofuran) with stirring under nitrogen at room temperature. The resulting reaction mixture is stirred at room temperature for 2 hours. tert-Butyl N-allyl-N-[2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate (3.4 g, 13.16 mmol) in tetrahydrofuran (15 mL) is then added drop wise at room temperature and the resulting mixture is stirred overnight. Dilute aqueous hydrochloric acid is added followed by ethyl acetate. The layers are separated and the aqueous phase is re-extracted with ethyl acetate. The combined organic extracts are dried over magnesium sulfate, filtered, and concentrated to dryness under reduced pressure. The resulting residue is purified by silica gel column chromatography using a 0-40% gradient of acetone in iso-hexane to give the title compound (1.27 g, 33%). ES/MS (m/e): 317 (M+23).

1. customThe resulting reaction mixture
2. stirringis stirred at room temperature for 2 hours
3. stirringthe resulting mixture is stirred overnight
4. customThe layers are separated
5. extractionthe aqueous phase is re-extracted with ethyl acetate
6. dry with materialThe combined organic extracts are dried over magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated to dryness under reduced pressure
9. customThe resulting residue is purified by silica gel column chromatography