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HRID521881

反应详情

EQUATION

反应方程式

HRID 521881 的结构方程式

REACTANTS

反应物

2
结构：Cn1ncc(NC(=O)c2nc(Br)sc2NC(=O)OC(C)(C)C)c1C12CCC(NC(=O)OC(C)(C)C)C(CC1)O2
HCID86713819

未命名化合物

结构：Cn1ncc([N+](=O)[O-])c1[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)[C@@H](F)CO1
HCID86713831

未命名化合物

2 次

PRODUCTS

生成物

1
结构：Cn1ncc(NC(=O)c2nc(Br)sc2NC(=O)OC(C)(C)C)c1[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)[C@@H](F)CO1
HCID86713830

未命名化合物

PROCEDURE

实验过程

Following the procedure for Intermediate 65 starting from tert-butyl ((3R,4R,7S)-3-fluoro-7-(1-methyl-4-nitro-1H-pyrazol-5-yl)oxepan-4-yl)carbamate (Intermediate 24) gave tert-butyl N-[2-bromo-4-[[5-[(2S,5R,6R)-5-(tert-butoxycarbonylamino)-6-fluoro-oxepan-2-yl]-1-methyl-pyrazol-4-yl]carbamoyl]thiazol-5-yl]carbamate as a solid (350 mg, 73% over two steps). 1H NMR (400 MHz, CDCl3) δ 10.34 (s, 1H), 9.31 (s, 1H), 7.98 (s, 1H), 5.15-4.98 (m, 1H), 4.93 (d, J=9.0 Hz, 1H), 4.77 (d, J=8.7 Hz, 1H), 4.39-3.94 (m, 2H), 3.80 (s, 3H), 2.12-1.93 (m, 4H), 1.85 (d, J=11.0 Hz, 1H), 1.52 (s, 9H), 1.46 (s, 9H).