反应详情

Under a blanket of nitrogen 0.3 g of 2-(1-{[5-(benzyloxy)-2-methylphenyl]carbonyl}piperidin-4-yl)-5-(7-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (compound described in example 88) are dissolved in 20 ml of methanol and 0.04 g palladium on charcoal (10%) and 0.32 g ammonium formiate are added. The reaction mixture is heated to reflux or 4 h until the starting material is consumed according to TLC analysis. The mixture is filtered over a plug of celite, and the solvent is removed under reduced pressure resulting in the crude product, which is purified by column chromatography (amino phase silica gel and DCM) to yield the title compound.

1. temperatureThe reaction mixture is heated
2. temperatureto reflux or 4 h until the starting material
3. customis consumed
4. filtrationThe mixture is filtered over a plug of celite
5. customthe solvent is removed under reduced pressure
6. customresulting in the crude product, which
7. customis purified by column chromatography (amino phase silica gel and DCM)