反应详情

Ethyl 2-[6-[[2-(4-cyclopropylsulfonylphenyl)-2-tetrahydropyran-4-yloxy-acetyl]amino]-2-pyridyl]acetate (Example A9; 0.4 g, 0.796 mmol) was taken in THF(12 mL) and EtOH (4 mL), to it was added aqueous solution of LiOH (0.033 g, 0.796 mmol in 4 mL water) and stirred for 1 h at room temperature. Completion of reaction was confirmed by TLC. Organic solvent was removed under reduced pressure. The obtained residue was diluted with water (50 mL) and washed with ethyl acetate (2×20 mL). The aqueous layer was acidified with 1N HCl to pH 1-2 and extracted with Ethyl acetate (3×50 mL). The combined organic layer was washed with brine (50 mL) dried over anhydrous sodium sulphate and the solvent was removed under vacuum to get the pure product (0.320 g).

1. customCompletion of reaction
2. customOrganic solvent was removed under reduced pressure
3. additionThe obtained residue was diluted with water (50 mL)
4. washwashed with ethyl acetate (2×20 mL)
5. extractionextracted with Ethyl acetate (3×50 mL)
6. washThe combined organic layer was washed with brine (50 mL)
7. dry with materialdried over anhydrous sodium sulphate
8. customthe solvent was removed under vacuum