反应详情

The title compound was prepared in an analogous fashion to that described in Example 85 using 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)nicotinamide (Stage 48.2) and (S)-piperidin-3-ol hydrochloride to afford a white solid. UPLC-MS (Condition 3) tR=0.99 min, m/z=464.1 [M+H]+, m/z=508.1 [M+formic acid-H]−; 1H NMR (400 MHz, DMSO-d6) δ ppm 1.19-1.35 (m, 1H) 1.37-1.52 (m, 1H) 1.56-1.70 (m, 1H) 1.78-1.93 (m, 1H) 2.53-2.64 (m, 1H) 2.65-2.81 (m, 1H) 3.43 (d, J=12.72 Hz, 1H) 3.51-3.61 (m, 1H) 3.65 (d, J=12.23 Hz, 1H) 4.72-4.83 (m, 1H) 6.54-6.69 (m, 1H) 7.34 (d, J=8.93 Hz, 2H) 7.54-7.86 (m, 1H) 7.88 (d, J=9.05 Hz, 2H) 8.15-8.37 (m, 1H) 8.68-8.78 (m, 1H) 10.31-10.46 (m, 1H) 12.96-13.18 (m, 1H).

1. customto afford a white solid