Cyclopropylamine → HCID 178487649, compound

HRID 526524Notes

Reaction equation

HRID 526524 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([O:22][CH3:23])[CH:17]=1.[CH:24]1([NH2:27])[CH2:26][CH2:25]1>>[CH:24]1([NH:27][C:11](=[O:12])[C:10]2[CH:14]=[CH:15][C:7]([N:6]3[C:2]([OH:1])=[C:3]([C:16]4[CH:21]=[CH:20][N:19]=[C:18]([O:22][CH3:23])[CH:17]=4)[CH:4]=[N:5]3)=[N:8][CH:9]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 178487655HCID 178487655, compound

Product 1

HCID 178487649HCID 178487649, compound

Procedure

The title compound was prepared in a manner similar to Example 198 using 6-(5-hydroxy-4-(2-methoxypyridin-4-yl)-1H-pyrazol-1-yl)nicotinic acid and cyclopropanamine. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.49-0.57 (m, 2H) 0.63-0.71 (m, 2H) 2.80 (td, J=7.3, 3.8 Hz, 1H) 3.82 (s, 3H) 7.41 (br. s., 1H) 7.48 (d, J=5.6 Hz, 1H) 8.01 (d, J=5.8 Hz, 1H) 8.27-8.35 (m, 1H) 8.38 (br. s., 1H) 8.51-8.68 (m, 2H) 8.76-8.85 (m, 1H). MS m/z 352 [M+H]+.

Sources & evidence

ORD record
ord-3c0f0b0a8a514d3db05351d17d7aa375
Source dataset
uspto-grants-2016_05
Patent number
US09345713B2

Reaction notes

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