Methanesulfonyl chloride → 3-methyl-5-{[(methyloxy)methyl]oxy}-3,4-dihydro-2H-chromene

Temperature

0 °C

In a 50 ml round-bottomed flask under argon, 2-(3-hydroxy-2-methylpropyl)-3-{[(methyloxy)methyl]oxy}phenol (Intermediate 115, 377.9 mg) was dissolved in tetrahydrofuran (5 ml) to give a colourless solution. TEA (0.409 ml, 2.93 mmol) was added and the reaction mixture was cooled at 0° C. At that temperature methanesulfonyl chloride (0.124 ml, 1.591 mmol) was added. The reaction mixture was stirred at 0° C. After 45 minutes, additional methanesulfonyl chloride (0.124 ml, 1.591 mmol) was added. After additional 45 minutes, potassium 2-methyl-2-propanolate (422 mg, 3.76 mmol) was added. After 15 minutes from this latter addition, additional potassium 2-methyl-2-propanolate (422 mg, 3.76 mmol) was added. After 15 minutes the reaction was completed. The reaction was then quenched with 10 ml of a saturated aqueous solution of NH4Cl, acidified until pH˜2 with 2M hydrochloric acid and diluted with 25 ml of dichloromethane. Phases were separated through a phase separator cartridge. The organic phase was evaporated under vacuum to afford the title compound.

1. customto give a colourless solution
2. waitAfter additional 45 minutes
3. additionwas added
4. waitAfter 15 minutes the reaction was completed
5. customThe reaction was then quenched with 10 ml of a saturated aqueous solution of NH4Cl
6. additiondiluted with 25 ml of dichloromethane
7. customPhases were separated through a phase separator cartridge
8. customThe organic phase was evaporated under vacuum

ORD record

ord-8946e51948fb4d96acdfe48949e1baa9

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09346790B2