反应详情

Compound I-38 was prepared according to the method in example 42, using 6-[2-(4-piperidyl)ethyl]spiro[[1,3]dioxolo[4,5-f]isoindole-7,1′-cyclopropane]-5-one hydrochloride (compound II-5) and 3-bromomethylpyridazine hydrobromide as the raw materials: 1H NMR(CDCl3): δ 1.25-1.37 (m, 5H), 1.49-1.58 (m, 4H), 1.73 (d, 2H, J=11.2 Hz), 2.14 (t, 2H, J=10.7 Hz), 2.82 (d, 2H, J=11.6 Hz), 3.19 (t, 2H, J=7.8 Hz), 3.85 (s, 2H), 6.03 (s, 2H), 6.43 (s, 1H), 7.23 (s, 1H), 7.46 (dd, 1H, J=8.4, 4.9 Hz), 7.67 (d, 1H, J=8.0 Hz), 9.08 (dd, 1H, J=4.8, 1.4 Hz): m/z 407 [M+H]+.

1. customCompound I-38 was prepared