反应详情

1.07 g of the phthalimide compound thus obtained was dissolved in 15 ml of tetrahydrofuran, and 2.6 ml of a 1M tetrahydrofuran solution of tetrabutylammonium fluoride was added thereto. The mixture was stirred at room temperature overnight. The reaction solution was evaporated to dryness under reduced pressure. Then, the residue was dissolved in a liquid mixture of water and ethyl ether. The organic layer was collected by separation and then dried over anhydrous magnesium sulfate. The drying agent was separated by filtration, and then the solvent was distilled off under reduced pressure. The residue was subjected to medium pressure liquid chromatography (hexane/ethyl acetate=4/1→2/1) to obtain 0.39 g (yield: 47%) of N-{(1RS, 2SR)-2-(3,4-dichlorobenzyl)-3-hydroxy-1-methylpropyl}phthalimide.

1. customThe reaction solution was evaporated to dryness under reduced pressure
2. dissolutionThen, the residue was dissolved in a liquid mixture of water and ethyl ether
3. customThe organic layer was collected by separation
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe drying agent was separated by filtration
6. distillationthe solvent was distilled off under reduced pressure