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HRID529578

反应详情

EQUATION

反应方程式

HRID 529578 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)C=CCN(c2ccccc2)C(=O)C1N
HCID68292320

未命名化合物

结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)O)Cc3ccccc3)C(=O)N21
HCID68311179

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)N[C@@H]3C(=O)N(c4ccccc4)CC=CC3(C)C)Cc3ccccc3)C(=O)N21
HCID68311199

未命名化合物

PROCEDURE

实验过程

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-((S,Z)-4,4-dimethyl-2-oxo-1-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-ylamino)-6-oxohexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (10 mg, 0.018 mmol) and Intermediate 33 (4.1 mg, 0.018 mmol) to give a white solid (4.0 mg, 27% yield). Anal. Calcd. for C45H54N4O6S m/z 778.4. found: 779.4 (M+H)+; 1H NMR (500 MHz, CD3OD) δ ppm 8.00-8.08 (m, 1H), 7.31 (t, J=7.70 Hz, 2H), 7.27-7.09 (m, 11H), 6.98 (d, J=7.70 Hz, 2H), 5.77 (ddd, J=11.41, 8.11, 3.57 Hz, 1H), 5.63-5.49 (m, 2H), 5.38 (d, J=9.35 Hz, 1H), 5.04-4.97 (m, 1H), 4.96-4.90 (m, 1H), 3.75 (dd, J=17.60, 8.25 Hz, 1H), 3.59 (s, 3H), 3.03-2.88 (m, 2H), 2.84-2.65 (m, 5H), 2.62-2.53 (m, 1H), 2.34 (d, J=13.75 Hz, 1H), 2.16-2.01 (m, 1H), 1.96 (d, J=10.45 Hz, 1H), 1.89-1.79 (m, 2H), 1.76-1.47 (m, 6H), 1.41-1.30 (m, 1H), 0.89-0.80 (s, 3H), 0.54-0.46 (s, 3H).