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HRID529593

反应详情

EQUATION

反应方程式

HRID 529593 的结构方程式

REACTANTS

反应物

2
结构：N[C@H]1C/C=C\CCN(Cc2ccccc2)C1=O
HCID68292242

未命名化合物

结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)O)Cc3ccccc3)C(=O)N21
HCID68311179

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)N[C@H]3C/C=C\CCN(Cc4ccccc4)C3=O)Cc3ccccc3)C(=O)N21
HCID66547009

未命名化合物

PROCEDURE

实验过程

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-((S,Z)-1-benzyl-2-oxo-1,2,3,4,7,8-hexahydroazocin-3-ylamino)-6-oxohexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (8.0 mg, 0.014 mmol) and Intermediate 44 (6.5 mg, 0.028 mmol) to give a white solid (6.8 mg, 61% yield). Anal. Calcd. for C45H54N4O6S m/z 778.7. found: 779.3 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.40-7.05 (m, 17H), 5.48-5.26 (m, 4H), 5.18-5.06 (m, 1H), 5.05-4.93 (m, 3H), 4.84 (d, J=14.8 Hz, 1H), 4.17 (d, J=14.8 Hz, 1H), 3.92-3.75 (m, 1H), 3.67 (s, 3H), 3.14 (dt, J=14.3, 8.7 Hz, 2H), 2.87-2.66 (m, 5H), 2.61-2.32 (m, 6H), 2.25 (dt, J=16.4, 8.0 Hz, 1H), 2.06-1.97 (m, 2H), 1.86-1.44 (m, 7H).