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HRID529594

反应详情

EQUATION

反应方程式

HRID 529594 的结构方程式

REACTANTS

反应物

2
结构：N[C@H]1CCCCCN(Cc2ccccc2)C1=O.O=C(O)C(F)(F)F
HCID68292569

未命名化合物

结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)O)Cc3ccccc3)C(=O)N21
HCID68311179

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)N[C@H]3CCCCCN(Cc4ccccc4)C3=O)Cc3ccccc3)C(=O)N21
HCID86706248

未命名化合物

PROCEDURE

实验过程

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-((S)-1-benzyl-2-oxoazocan-3-ylamino)-6-oxohexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (11 mg, 0.019 mmol) and Intermediate 45 (6.3 mg, 0.027 mmol) to give a white solid (9.5 mg, 62% yield). Anal. Calcd. for C45H56N4O6S m/z 780.7. found: 781.3 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.40-7.03 (m, 16H), 6.81 (d, J=7.4 Hz, 1H), 5.34 (t, J=4.6 Hz, 1H), 5.13 (d, J=6.1 Hz, 1H), 5.07 (d, J=14.7 Hz, 1H), 5.03-4.93 (m, 1H), 4.92-4.80 (m, 1H), 4.06 (d, J=14.7 Hz, 1H), 3.77 (t, J=13.2 Hz, 1H), 3.68 (s, 3H), 3.25-3.04 (m, 2H), 2.92-2.64 (m, 5H), 2.47-2.29 (m, 2H), 2.12-1.95 (m, 2H), 1.90-1.09 (m, 18H).