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HRID529600

反应详情

EQUATION

反应方程式

HRID 529600 的结构方程式

REACTANTS

反应物

2
结构：N[C@H]1CC=CCN(Cc2ccccc2)C1=O
HCID68292696

未命名化合物

结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)O)Cc3ccccc3)C(=O)N21
HCID68311179

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)N[C@H]3CC=CCN(Cc4ccccc4)C3=O)Cc3ccccc3)C(=O)N21
HCID86706249

未命名化合物

PROCEDURE

实验过程

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-((S,Z)-1-benzyl-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-ylamino)-6-oxohexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (11 mg, 0.019 mmol) and Intermediate 51 (5.9 mg, 0.027 mmol) to give a white solid (10 mg, 68% yield). Anal. Calcd. for C44H52N4O6S m/z 764.4. found: 765.2 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.41-7.06 (m, 16H), 6.96 (d, J=7.1 Hz, 1H), 5.67-5.48 (m, 2H), 5.34 (t, J=4.6 Hz, 1H), 5.18-5.06 (m, 2H), 5.05-4.93 (m, 1H), 4.61 (dd, J=51.2, 15.0 Hz, 2H), 4.34 (d, J=17.6 Hz, 1H), 3.67 (s, 3H), 3.33 (dd, J=17.6, 6.8 Hz, 1H), 3.14 (t, J=11.4 Hz, 1H), 2.91-2.64 (m, 4H), 2.51-2.14 (m, 6H), 2.02 (d, J=4.4 Hz, 2H), 1.89-1.44 (m, 9H).