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HRID529606

反应详情

EQUATION

反应方程式

HRID 529606 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)O)Cc3ccccc3)C(=O)N21
HCID68311179

未命名化合物

结构：Cl.N[C@H]1CCCC[C@H]2CCCCN2C1=O
HCID86706219

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)N[C@H]3CCCC[C@H]4CCCCN4C3=O)Cc3ccccc3)C(=O)N21
HCID68309894

未命名化合物

PROCEDURE

实验过程

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-oxo-6-((7S,11aS)-6-oxodecahydro-1H-pyrido[1,2-a]azocin-7-ylamino)hexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (11 mg, 0.019 mmol) and Intermediate 56 (5.0 mg, 0.021 mmol) to give a white solid (11 mg, 80% yield). Anal. Calcd. for C42H56N4O6S m/z 744.4. found: 745.3 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.28-7.08 (11H, m), 7.05 (1H, d, J=7.1 Hz), 5.33 (1H, t, J=4.7 Hz), 5.15-5.09 (1H, m), 5.04-4.95 (1H, m), 4.82-4.73 (1H, m), 4.39 (1H, d, J=13.2 Hz), 4.16 (1H, d, J=12.6 Hz), 3.68 (3H, s), 3.16 (1H, t, J=11.5 Hz), 2.87-2.69 (5H, m), 2.52 (1H, td, J=13.2, 2.7 Hz), 2.46-2.34 (3H, m), 2.15 (1H, t, J=13.5 Hz), 2.07-1.99 (2H, m), 1.94-1.77 (2H, m), 1.76-1.37 (16H, m), 1.36-1.19 (2H, m), 1.08-0.94 (1H, m), 0.89-0.76 (1H, m).