huagongshe.com
HRID529607

反应详情

EQUATION

反应方程式

HRID 529607 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)O)Cc3ccccc3)C(=O)N21
HCID68311179

未命名化合物

结构：N[C@H]1CCS[C@H]2CC[C@H](C(F)(F)F)CN2C1=O
HCID86706221

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)N[C@H]3CCS[C@H]4CC[C@H](C(F)(F)F)CN4C3=O)Cc3ccccc3)C(=O)N21
HCID86706250

未命名化合物

PROCEDURE

实验过程

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-oxo-6-((4S,8S,10aS)-5-oxo-8-(trifluoromethyl)octahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylamino)hexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (11 mg, 0.019 mmol) and Intermediate 60 (6.3 mg, 0.023 mmol) to give a white solid (10 mg, 65% yield). Anal. Calcd. for C41H51F3N4O6S2 m/z 816.4. found: 817.3 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.34-7.05 (m, 10H), 6.87 (d, J=6.3 Hz, 2H), 5.33 (t, J=4.6 Hz, 1H), 5.22-5.07 (m, 2H), 5.05-4.93 (m, 1H), 4.84-4.71 (m, 1H), 4.37 (d, J=14.8 Hz, 1H), 3.69 (s, 3H), 3.33-3.10 (m, 3H), 2.92-2.51 (m, 7H), 2.48-2.20 (m, 4H), 2.12-1.92 (m, 3H), 1.93-1.76 (m, 2H), 1.77-1.19 (m, 11H).