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HRID529620

反应详情

EQUATION

反应方程式

HRID 529620 的结构方程式

REACTANTS

反应物

2
结构：COc1ccccc1N1CCCC[C@H](NC(=O)[C@H](CC[C@H](Cc2ccccc2)C(=O)O)Cc2ccccc2)C1=O
HCID68310532

未命名化合物

结构：N[C@H]1CCS[C@H]2CCC[C@@H](C(F)(F)F)N2C1=O
HCID86706238

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccccc1N1CCCC[C@H](NC(=O)[C@H](CC[C@H](Cc2ccccc2)C(=O)N[C@H]2CCS[C@H]3CCC[C@@H](C(F)(F)F)N3C2=O)Cc2ccccc2)C1=O
HCID86706255

未命名化合物

PROCEDURE

实验过程

(2R,5R)-2,5-Dibenzyl-N1-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-yl)-N6-((4S,7S,10aS)-5-oxo-7-(trifluoromethyl)octahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)hexanediamide was synthesized as described in General Procedure H using Intermediate 70 (19 mg, 0.035 mmol) and Intermediate 77 (9.0 mg, 0.034 mmol) to give a white solid (25 mg, 90% yield). Anal. Calcd. for C43H51F3N4O5S m/z 792.7. found: 793.3 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.40-6.82 (m, 16H), 5.21 (t, J=6.7 Hz, 2H), 4.97-4.84 (m, 2H), 4.76 (t, 1H), 3.98-3.82 (m, 1H), 3.79 (s, 3H), 3.46-3.30 (m, 1H), 3.25-3.08 (m, 1H), 2.93-2.75 (m, 2H), 2.75-2.53 (m, 3H), 2.44-2.29 (m, 3H), 2.21-1.28 (m, 16H).