(4S,7R,10aS)-4-Amino-7-methylhexahydro-2H-pyrido[2,1-b][1,3]thiazepin-5(7H)-one → (2R,5R)-2,5-Dibenzyl-N1-((4S,7R,10aS)-7-methyl-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)-N6-((S)-2-oxo-1-o-tolylazepan-3-yl)hexanediamide

HRID 529622Notes

Reaction equation

HRID 529622 reaction equation
[CH2:1]([C@@H:8]([CH2:12][CH2:13][C@H:14]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:15](=[O:32])[NH:16][C@H:17]1[CH2:23][CH2:22][CH2:21][CH2:20][N:19]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[C:18]1=[O:31])[C:9](O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:40][C@H:41]1[CH2:47][CH2:46][S:45][C@H:44]2[CH2:48][CH2:49][CH2:50][C@@H:51]([CH3:52])[N:43]2[C:42]1=[O:53]>>[CH2:1]([C@@H:8]([CH2:12][CH2:13][C@H:14]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:15]([NH:16][C@H:17]1[CH2:23][CH2:22][CH2:21][CH2:20][N:19]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[C:18]1=[O:31])=[O:32])[C:9]([NH:40][C@H:41]1[CH2:47][CH2:46][S:45][C@H:44]2[CH2:48][CH2:49][CH2:50][C@@H:51]([CH3:52])[N:43]2[C:42]1=[O:53])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 60127973(4S,7R,10aS)-4-Amino-7-methylhexahydro-2H-pyrido[2,1-b][1,3]thiazepin-5(7H)-oneHCID 68292933(2R,5R)-2,5-Dibenzyl-6-oxo-6-((S)-2-oxo-1-o-tolylazepan-3-ylamino)hexanoic acid

Product 1

HCID 86706257(2R,5R)-2,5-Dibenzyl-N1-((4S,7R,10aS)-7-methyl-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)-N6-((S)-2-oxo-1-o-tolylazepan-3-yl)hexanediamide

Procedure

(2R,5R)-2,5-Dibenzyl-N1-((4S,7R,10aS)-7-methyl-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)-N6-((S)-2-oxo-1-o-tolylazepan-3-yl)hexanediamide was synthesized as described in General Procedure H using Intermediate 71 (17 mg, 0.031 mmol) and Intermediate 72 (7.5 mg, 0.035 mmol) to give a white solid (18 mg, 69% yield). Anal. Calcd. for C43H54N4O4S m/z 722.7. found: 723.5 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.37-6.88 (m, 14H), 5.28 (d, J=5.2 Hz, 1H), 4.99-4.85 (m, 1H), 4.83-4.70 (m, 1H), 4.66-4.56 (m, 1H), 4.09-3.83 (m, 2H), 3.53 (d, J=14.5 Hz, 1H), 3.31 (dd, J=15.0, 5.0 Hz, 1H), 3.15-2.93 (m, 4H), 2.90-2.64 (m, 4H), 2.63-2.49 (m, 2H), 2.48-2.30 (m, 3H), 2.19 and 2.13 (s, 3H), 2.09-1.43 (m, 11H), 1.32 (d, J=6.9 Hz, 3H), 1.44-1.16 (m, 2H).

Sources & evidence

ORD record
ord-e972466a59394cf6a0e32de92e7c3008
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

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