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HRID529624

反应详情

EQUATION

反应方程式

HRID 529624 的结构方程式

REACTANTS

反应物

2
结构：COc1ccccc1N1CCCC[C@H](NC(=O)[C@H](CC[C@H](Cc2ccccc2)C(=O)O)Cc2ccccc2)C1=O
HCID68310532

未命名化合物

结构：C=C[C@@H]1CCC[C@@H]2SCC[C@H](N)C(=O)N12
HCID86706234

未命名化合物

PRODUCTS

生成物

1
结构：C=C[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)N[C@H]3CCCCN(c4ccccc4OC)C3=O)Cc3ccccc3)C(=O)N12
HCID68311191

未命名化合物

PROCEDURE

实验过程

(2R,5R)-2,5-Dibenzyl-N1-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-yl)-N6-((4S,7S,10aS)-5-oxo-7-vinyloctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)hexanediamide was synthesized as described in General Procedure H using Intermediate 70 (36 mg, 0.067 mmol) and Intermediate 73 (23 mg, 0.067 mmol) to give a white solid (30 mg, 59% yield). Anal. Calcd. for C44H54N4O5S m/z 750.7. found: 751.5 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.29-7.07 (m, 11H), 7.07-6.89 (m, 3H), 6.36-6.18 (m, 1H), 5.33 (s, 1H), 5.23 (d, J=17.1 Hz, 1H), 5.12 (d, J=10.3 Hz, 1H), 5.06-4.90 (m, 2H), 4.84-4.70 (m, 1H), 4.02-3.84 (m, 1H), 3.79 (s, 3H), 3.47-3.29 (m, 1H), 3.04-2.89 (m, 1H), 2.89-2.75 (m, 2H), 2.75-2.64 (m, 1H), 2.61-2.47 (m, 1H), 2.46-2.23 (m, 8H), 2.10-1.55 (m, 11H), 1.54-1.42 (m, 2H), 1.39-1.15 (m, 2H).