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HRID529631

反应详情

EQUATION

反应方程式

HRID 529631 的结构方程式

REACTANTS

反应物

2
结构：CCC[C@@H](CC[C@H](Cc1ccc(F)cc1)C(=O)O)C(=O)N[C@H]1CCCCN(c2ccccc2OC)C1=O
HCID68311019

未命名化合物

结构：N[C@H]1CCS[C@H]2CCC[C@@H](C(F)(F)F)N2C1=O
HCID86706238

未命名化合物

PRODUCTS

生成物

1
结构：CCC[C@@H](CC[C@H](Cc1ccc(F)cc1)C(=O)N[C@H]1CCS[C@H]2CCC[C@@H](C(F)(F)F)N2C1=O)C(=O)N[C@H]1CCCCN(c2ccccc2OC)C1=O
HCID68310558

未命名化合物

PROCEDURE

实验过程

(2R,5S)-2-(4-Fluorobenzyl)-N6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-yl)-N1-((4S,7S,10aS)-5-oxo-7-(trifluoromethyl)octahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)-5-propylhexanediamide was synthesized as described in General Procedure H using Intermediate 76 (22 mg, 0.043 mmol) and Intermediate 77 (12 mg, 0.045 mmol) to give a white solid (14 mg, 43% yield). Anal. Calcd. for C39H50F4N4O5S m/z 762.7. found: 763.3 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.42-7.22 (3H, m), 7.15-7.02 (3H, m), 7.01-6.94 (2H, m), 6.86 (2H, t, J=8.5 Hz), 5.28-5.15 (2H, m), 4.99-4.83 (2H, m), 4.05-3.88 (1H, m), 3.81 (3H, s), 3.54-3.34 (1H, m), 3.28-3.09 (1H, m), 2.85-2.60 (3H, m), 2.42-2.30 (1H, m), 2.22-1.72 (12H, m), 1.71-1.20 (11H, m), 0.87 (3H, t, J=7.1 Hz).