反应详情

1.7 g (3.5 mmol) of tert-butyl [(R)-2-(3-cyclopropylmethoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-oxoethyl]carbamate are placed in 45 ml of a 3M solution of hydrogen chloride in ethyl acetate and are stirred at room temperature for 3 hours. After evaporation under a stream of nitrogen, the crude product is taken up in a mixture of heptane and ethyl acetate, and then concentrated under vacuum. 1.6 g (100%) of (R)-2-amino-1-(3-cyclopropylmethoxy-3-o-tolylazetidin-1-yl)-3-(4-methoxyphenyl)propan-1-one hydrochloride are obtained in the form of a beige-coloured solid.

1. customAfter evaporation under a stream of nitrogen
2. additionthe crude product is taken up in a mixture of heptane and ethyl acetate
3. concentrationconcentrated under vacuum