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HRID531344

反应详情

EQUATION

反应方程式

HRID 531344 的结构方程式

REACTANTS

反应物

3
结构：NS(=O)(=O)C1CC1
HCID15765418

Cyclopropanesulfonamide

C3H7NO2S

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCN(C)C(=O)C4C3)cc(-c3nc(C(C)C)cs3)nc2c1C
HCID66811198

未命名化合物

结构：COc1ccc2c(OC3CC4C(=O)NCCCCCC=CC5CC5(C(=O)O)NC(=O)C4C3)cc(-c3nc(C(C)C)cs3)nc2c1C
HCID66872141

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2c(OC3CC4C(=O)NCCCCCC=CC5CC5(C(=O)NS(=O)(=O)C5CC5)NC(=O)C4C3)cc(-c3nc(C(C)C)cs3)nc2c1C
HCID66871489

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 18-[2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-2,15-dioxo-3,14-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid (80) and cyclopropylsulfonamide following the procedure reported for the preparation of N-[17-[2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide (47): m/z=750 (M+H)+. 1H NMR (CDCl3): 0.90-0.96 (m, 1H), 1.1-1.2 (m, 4H), 1.39 (d, J=6.9 Hz, 6H), 1.4-1.55 (m, 5H), 1.80-1.92 (m, 5H), 2.15-2.25 (m, 1H), 2.30-2.40 (m, 1H), 2.45-2.55 (m, 2H), 2.68 (s, 3H), 2.85-2.92 (m, 1H), 3.15-3.30 (m, 2H), 3.45-3.55 (m, 2H), 3.96 (s, 3H), 4.09 (dd, J=11.5 Hz, J=3.8 Hz, 1H), 4.61 (t, J=7.9 Hz, 1H), 4.99 (t, J=9.0 Hz, 1H), 5.51-5.53 (m, 1H), 5.71 (dd, J=18.6 Hz, J=8.2 Hz, 1H), 6.86 (s, 1H), 7.03 (s, 1H), 7.20 (d, J=9.2 Hz, 1H), 7.50 (s, 1H), 7.88 (d, J=9.2 Hz, 1H), 9.40 (br s, 1H).