Lithium Hydroxide → N-(3-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-dimethoxyphenyl)methanesulfonamide

HRID 531522Notes

Reaction equation

HRID 531522 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:47]=[CH:48][CH:49]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[C:9]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[C:18]([C:21]4[C:22]([O:34][CH3:35])=[C:23]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])[C:24]([O:27][CH3:28])=[CH:25][CH:26]=4)[CH:19]=3)[N:14](S(C3C=CC(C)=CC=3)(=O)=O)[CH:13]=2)[C:8]([CH3:46])=[N:7]1.[OH-].[Li+]>C1COCC1.CO.O>[F:1][C:2]1[CH:3]=[C:4]([CH:47]=[CH:48][CH:49]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[C:9]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[C:18]([C:21]4[C:22]([O:34][CH3:35])=[C:23]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])[C:24]([O:27][CH3:28])=[CH:25][CH:26]=4)[CH:19]=3)[NH:14][CH:13]=2)[C:8]([CH3:46])=[N:7]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 90030283N-(3-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-dimethoxy phenyl)methanesulfonamide

Product 1

HCID 72943388N-(3-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-dimethoxyphenyl)methanesulfonamideYield 25.9%

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

Using similar reaction conditions as described in step-iii of example-1, N-(3-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-dimethoxy phenyl)methanesulfonamide (40 mg, 0.05 mmol) was hydrolyzed by lithium hydroxide (23.8 mg, 0.5 mmol), THF/Methanol/water (12/4/4 ml) to afford 7 mg (25.9% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.5 (b, 1H), 8.181-8.177 (d, 1H), 7.525 (s, 1H), 7.356-7.334 (m, 2H), 6.991-6.957 (m, 3H), 6.9-6.85 (m, 1H), 5.363 (s, 2H), 3.930 (s, 3H), 3.499 (s, 3H), 3.184 (s, 1H), 2.231-2.204 (d, 6H). MS: m/z=550.0 (M+1); HPLC: 94.463% in method A.

Workup

  1. customreaction conditions

Sources & evidence

ORD record
ord-f10d631126ef46ccb4fed133429f9809
Source dataset
uspto-grants-2016_05
Patent number
US09353107B2

Reaction notes

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