反应详情

Using similar reaction conditions as described in step-iii of example-1, N-(5-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-morpholino phenyl)methanesulfonamide (150 mg, 0.205 mmol) was hydrolyzed with lithium hydroxide (43.2 mg, 1.02 mmol) in THF/Methanol/water (2/3/1 ml). This yielded 23 mg (19.49% yield) of pure compound. 1H NMR (CDCl3, 300 MHz): δ 9.17 (s, 1H), 8.55 (s, 1H), 7.86 (s, 2H), 7.75 (s, 1H), 7.32 (s, 3H), 6.99-6.97 (m, 2H), 6.90-6.80 (d, 1H), 5.31 (s, 2H), 3.91-3.88 (m, 4H), 3.10 (s, 3H), 2.92-2.89 (m, 4H), 2.26 (s, 3H), 2.17 (s, 3H). MS: m/z=575.1 (M+1), HPLC Purity: 98.92% Method: B.

1. customreaction conditions