HRID531575
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Using similar reaction conditions as described in Step-ii of example-7, tert-butyl 5-(4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)-6-cyclopropyl-3-(1-(3,5-difluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (62 mg, 0.022 mmol) was deprotected in HCl in methanol (2 ml). This afforded 4 mg (5% yield) of the titled compound. 1H NMR (CDCl3, 300 MHz): δ 8.44 (b, 1H), 7.68 (s, 1H), 7.42-7.39 (d, 2H), 7.02-7.00 (d, 2H), 6.661-6.641 (m, 1H), 6.311-6.305 (d, 1H), 5.26 (s, 2H), 3.25-3.21 (m, 3H), 3.10-3.07 (t, 3H), 2.41 (s, 3H), 2.32 (s, 3H), 1.13-1.10 (m, 2H), 0.88-0.85 (m, 4H). MS: m/z=539.2 (M+1).
WORKUP
后处理
- customreaction conditions