HRID531586

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：COc1ncc(-c2cnc3c(c2)c(-c2c(C)nn(Cc4cccc(F)c4)c2C)cn3C(=O)OC(C)(C)C)cc1NS(C)(=O)=O

HCID90031029

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1nn(Cc2cccc(F)c2)c(C)c1-c1c[nH]c2ncc(-c3cnc(O)c(NS(C)(=O)=O)c3)cc12

HCID178433947

未命名化合物

收率 11.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-5-(6-methoxy-5-(methylsulfonamido)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (61 mg, 0.098 mmol) was deprotected in HCl in MeOH (3 ml) to afford 5 mg (11.3% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.71-8.62 (d, 2H), 7.91-7.88 (d, 2H), 7.68 (s, 1H), 7.47-7.42 (m, 1H), 7.15-7.02 (m, 3H), 6.60 (s, 1H), 5.57 (s, 2H), 3.09 (s, 3H), 2.36 (s, 3H), 2.35 (s, 3H). MS: m/z=506.8 (M+1), HPLC: 90.22% in method B.

WORKUP

后处理

customreaction conditions