HRID531597

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：COc1ccc(-c2cnc3c(c2)c(-c2cnn(Cc4cccnc4)c2)cn3C(=O)OC(C)(C)C)cc1N(C(=O)OC(C)(C)C)S(C)(=O)=O

HCID131735669

未命名化合物

PRODUCTS

产物

反应SMILES：COc1ccc(-c2cnc3[nH]cc(-c4cnn(Cc5cccnc5)c4)c3c2)cc1NS(C)(=O)=O

HCID72944104

未命名化合物

收率 29%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID21864698

未命名化合物

PROCEDURE

实验过程

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 5-(3-(N-(tert-butoxycarbonyl)methylsulfonamido)-4-methoxyphenyl)-3-(1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (60 mg, 0.219 mmol) was deprotected in HCl in ether/MeOH (1/3 ml) to afford 13 mg (29% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.78 (s, 2H), 8.53 (s, 2H), 8.42-8.37 (m, 2H), 8.02 (s, 1H), 8.00-7.94 (m, 1H), 7.77-7.76 (m, 2H), 7.62-7.59 (dd, 1H), 7.24-7.21 (d, 1H), 5.66 (s, 2H), 3.98 (s, 3H), 2.99 (s, 3H). MS: m/z=475.1 (M+1), HPLC: 97.36% in method A.

WORKUP

后处理

customreaction conditions