反应详情

Using similar reaction conditions as described in step-iii of example-1, N-(5-(3-(1-(3,5-difluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-fluorophenyl)methane sulfonamide (53 mg, 0.184 mmol) was hydrolyzed by lithium hydroxide (18 mg, 0.407 mmol) in THF/methanol/water (15/5/5 ml) to yield 34 mg (85% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.44-8.43 (d, 1H), 8.35-8.34 (d, 1H), 8.23 (s, 1H), 7.953-7.951 (d, 1H), 7.80-7.77 (dd, 1H), 7.66 (s, 1H), 7.59-7.55 (m, 1H), 7.34-7.29 (m, 1H), 6.90-6.86 (m, 2H), 5.43 (s, 2H), 305 (s, 3H). MS: m/z=498.1 (M+1), HPLC: 93.19% in method B.

1. customreaction conditions