反应详情

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-((3-(3-(1-phenethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)amino)piperidine-1-carboxylate (150 mg, 0.209 mmol) was hydrolyzed by lithium hydroxide (18 mg, 0.418 mmol) in THF/methanol/water (5/1/1 ml) to yield 80 mg (67.7% yield) of the titled compound after column purification using 2% methanol in DCM as eluent. MS: m/z=562.9 (M+1).

1. customreaction conditions