HRID531672
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Using similar reaction conditions as described in step-iii of example-1, (S)-1-(4-(5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl)piperidin-1-yl)propan-2-ol (86 mg, 0.129 mmol) was hydrolyzed by lithium hydroxide (54 mg, 1.293 mmol) in THF/methanol/water (15/7/4 ml) to yield 17 mg (25.7% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 9.01-9.00 (d, 1H), 8.56-8.55 (m, 2H), 8.45-8.42 (dd, 1H), 8.23 (s, 1H), 7.72 (s, 1H), 7.69-7.66 (d, 1H), 7.39-7.32 (m, 1H), 7.11-6.98 (m, 3H), 5.43 (s, 2H), 4.30-4.20 (m, 1H), 3.87-3.77 (t, 2H), 3.30-3.05 (m, 4H), 2.40-2.10 (m, 4H), 1.27-1.24 (d, 3H). MS: m/z=511.3 (M+1), HPLC: 96.17% in method A.
WORKUP
后处理
- customreaction conditions