HRID531714
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
产物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Using similar reaction conditions as described in step-iii of example-1, (S)-1-(4-(4-(3-(1-phenethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)propan-2-ol (100 mg, 0.151 mmol) was hydrolyzed with lithium hydroxide (13 mg, 0.302 mmol) in THF/methanol/water (5./1/1 mL) to yield 30 mg (31.9% yield) desired product. 1H NMR (CD3OD, 400 MHz): δ 8.56-8.55 (d, 1H), 8.49-8.48 (d, 1H), 7.90 (s, 1H), 7.84 (s, 1H), 7.73 (s, 1H), 7.68-7.66 (d, 2H), 7.26-7.19 (m, 4H), 7.14-7.10 (m, 3H), 4.47-4.44 (t, 2H), 4.30-4.25 (m, 1H), 3.99-3.94 (m, 2H), 3.78-3.74 (m, 2H), 3.31-3.21 (m, 2H), 3.19-3.12 (m, 4H), 1.29-1.28 (d, 3H). MS: m/z=507.60 (M+1), HPLC: 91.80% in method A.
WORKUP
后处理
- customreaction conditions