HCID 118523895, compound → HCID 118523928, compound

HRID 531716Notes

Reaction equation

HRID 531716 reaction equation
C([N:9]1[CH:13]=[C:12]([C:14]2[C:22]3[C:17](=[N:18][CH:19]=[C:20]([C:23]4[CH:28]=[CH:27][C:26]([N:29]5[CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31][CH2:30]5)=[CH:25][CH:24]=4)[CH:21]=3)[N:16]([S:42]([C:45]3[CH:51]=[CH:50][C:48]([CH3:49])=[CH:47][CH:46]=3)(=[O:44])=[O:43])[CH:15]=2)[CH:11]=[N:10]1)CC1C=CC=CC=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH2:20]([N:9]1[CH:13]=[C:12]([C:14]2[C:22]3[C:17](=[N:18][CH:19]=[C:20]([C:23]4[CH:24]=[CH:25][C:26]([N:29]5[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]5)=[CH:27][CH:28]=4)[CH:21]=3)[N:16]([S:42]([C:45]3[CH:46]=[CH:47][C:48]([CH3:49])=[CH:50][CH:51]=3)(=[O:43])=[O:44])[CH:15]=2)[CH:11]=[N:10]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 1

HCID 118523895HCID 118523895, compound

Product 1

HCID 118523928HCID 118523928, compoundYield 205%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-phenethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (200 mg, 0.290 mmol) was deprotected in TFA/DCM (2/5 ml) to afford 175 mg (85.7% yield) of the titled compound. MS: m/z=589.2 (M+1).

Workup

  1. customreaction conditions

Sources & evidence

ORD record
ord-2ecf7bb3071c41049f649e5af5fb85d6
Source dataset
uspto-grants-2016_05
Patent number
US09353107B2

Reaction notes

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