HRID531756
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Using similar reaction conditions as described in step-iii of example-1, 3-(1-(3,5-difluorobenzyl)-1H-pyrazol-4-yl)-5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (95 mg, 0.148 mmol) was hydrolyzed with lithium hydroxide (17 mg, 0.399 mmol) in THF/methanol/water (2/2/1 mL) to yield 30 mg (81.0% yield) of the titled compound. 1H NMR (CDCl3, 300 MHz): δ 9.14 (s, 1H), 8.49-8.46 (dd, 2H), 8.11 (s, 1H), 7.87 (s, 1H), 7.77-7.71 (m, 2H), 7.449-7.443 (d, 1H), 6.80-6.76 (m, 3H), 5.36 (s, 2H), 3.65-3.62 (m, 4H), 2.58-2.55 (m, 4H), 2.37 (s, 3H). MS: m/z=486.1 (M+1), HPLC: 93.44% in method B.
WORKUP
后处理
- customreaction conditions