反应详情

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-phenethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (130 mg, 0.238 mmol) was deprotected in methanolic HCl (5 ml). This afforded 78 mg (58.6% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.49 (s, 1H), 8.327-8.322 (d, 1H), 7.878-7.876 (d, 1H), 7.788-7.7.87 (d, 1H), 7.672-7.644 (m, 3H), 7.23-7.12 (m, 7H), 4.47-4.43 (t, 2H), 3.52-3.49 (m, 4H), 3.43-3.40 (m, 4H), 3.20-3.17 (t, 2H). MS: m/z=449.4 (M+1), HPLC: 95.50% in method A.

1. customreaction conditions