反应详情

温度

100 °C

To 7-bromo-4-chlorothieno[3,2-d]pyrimidine obtained in Step 1-3) of Preparation Example 1, t-butyl 4-hydroxypiperidine-1-carboxylate, K2CO3 and N,N-dimethylformamide were added, and stirred at 100° C. for 12 hours in a hermetically sealed reactor. The reaction mixture was cooled to room temperature, extracted with ethyl acetate and distilled water, and the organic layer thus obtained was washed with water and a saline solution. Subsequently, the washed organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the title compound.

1. additionwere added
2. temperatureThe reaction mixture was cooled to room temperature
3. extractionextracted with ethyl acetate
4. distillationdistilled water
5. customthe organic layer thus obtained
6. washwas washed with water
7. dry with materialSubsequently, the washed organic layer was dried over anhydrous sodium sulfate
8. concentrationconcentrated under reduced pressure